virtual desktops and edge accounts and teams

I'm looking at virtual desktops on Windows 11, so can sperate work and personal, couple of questions.
Can have edge accounts signed in different virtual desktops, example on personal desktop, edge would be signed in with personal Hotmail account and the work virtual desktop edge would be signed in with a domain work account, and exactly the same for teams, personal desktop, teams signed with personal Hotmail, and work virtual desktop signed in with domain work account teams.
I use the syncing features across both edges