I run these pretty much everyday:
1. Disk cleanup
2. CCleaner Portable (only specific things selected)
3. Emptying Temp folder
Scans usually when Defender shows the exclamation mark in Taskbar.
Windows is always up-to-date. I never understood why there are many complaints against updates.
I use Browser Compartmentalization. I have all the major browsers installed: Chrome, Edge, Firefox, Brave & Vivaldi. All of them have been configured with maximum security. Each browser is used for a very specific task, and I also use multiple profiles within each browser to minimize tracking as much as possible.
Everyone is collecting data these days. So Windows Firewall BLOCKS everything by default. Only the programs that need internet access for core functionality is allowed in the firewall. I don't mind running programs that are not up-to-date, as long as they function properly. I manually update them as and when needed.
Disks are trimmed/ defragged weekly.
Backups once in a while using Personal Backup. The important documents are all in the cloud, so they are always backed up.
I have a dual boot setup. The primary setup is on Windows 10 and I have only the most essential programs installed. The 2nd boot is Windows 11 and that is where all the fun and experimentation happens.
All data are stored in a separate disk, away from the operating systems.
Rest of the setup is explained in comment #2
here.