I used to use it back when I used panda. But windows defender has been doing a good job at staying near the effectiveness rate as panda. And it's not really necessary anymore. Any decent antivirus will do its job here. But as hdmi pointed out, autorun has been fixed but its still possible.
I just dont plug in any usbs other than my own systems, and the one I do plug into other systems, I use a hardware write protect switch to prevent anything from being copied to it. I stick that one into infected machines all the time to run my tools/scripts and other things.
Most of the apps I use are not in the microsoft store, however that is slowly changing. All the microsoft store apps I use are included out of the box like others have said, and I do find them useful. I actually use a few widgets from the microsoft store as well for the widgets panel. I also use a wifi analyzer tool on there to give me basic info.
Firefox is optional.
